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A member of the 2C drug family, 2C-B (2,5-dimethoxy-4-bromophenethylamine) is a psychedelic substance. It was initially synthesized by Alexander Shulgin in 1974. The dosage range is described as 12–24 mg in Shulgin’s book PHKAL. As a prescription medication, 2C-B for sale online is sometimes packaged in tablets or gel caps and is available for purchase online as a white powder. It is also known by a variety of street names. The medication is often taken orally, although it can also be inhaled (insufflated) or vaporized.

Aleksandr Shulgin synthesized 2C-B from 2,5-dimethoxybenzaldehyde in 1974, and it is now available for purchase online. The psychiatric community first noticed its use as an aid during therapy. The 2C-B available for purchase online was initially sold commercially as a prescription drug known as “Erox,” which was created by the German pharmaceutical company Drittewelle. It was offered as a table in Dutch department stores for a number of years under the brand name “Nexus.”

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Traditionally, psychedelics have been divided into two categories based on their chemical structure or primary mechanism of action: ergot hallucinogens (indolamines, such as psilocybin and LSD) and phenylethylamines, such as mescaline and 2,5-dimethyl-4-sodoamphetamine (DOI) (Vllenweer, 2001; Aarde and Taffe, 2017) However, new psychoactive substances (NPS) have recently emerged from both substitutions and well-known structures.

Such novel psychedelics include the 2C-series and its structural analogues, which include N-benzylphenethylamines (NBOMEs) (Tracy et al., 2017). A related class of substances known as 2C-series, often known as 2C-drugs or 2C-compounds, are thought to have psychedelic and stimulant properties.

They are all derivatives of phenylethylamine that are structurally similar to mescaline with methyl substitutions at the 2 and 5 positions and derived from the two carboon molecules between the benzene ring and the amino group. One of the oldest and best-known 2C-type medications is 2,5-dimethoxy-4-bromophenethylamine (Nexus, 2C-B).

Despite іtѕ іnіtіаl rерutаtіоn аѕ роtеntіаl рѕусhоthеrареutісаl drug аrоund the 1970ѕ, аnd later as an арhrоdіѕіас, оvеr thе lаѕt dесаdе 2C-B hаѕ gained рорulаrіtу among electronic music раrtу goers аѕ thе replacement of сhоісе for есѕtаѕу (MDMA, Mоllу) аnd LSD, either alone оr соmbіnеd (Gоnzálеz еt аl., 2013; Fеrnándеz-Cаldеrón еt аl., 2017).

Despite its initial reputation as a potential psychotherapeutic drug around the 1970s and later as an opiate, over the past decade, 2C-B has become more popular among attendees of electronic music festivals as an alternative to ecstasy (MDMA, Molly) and LSD, either alone or combined (González et al., 2013; Fernández-Calderón et al., 2017).

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The UN Commission on Narcotic Drugs added 2C-B and any of its salts or isomers to Schedule II of the 1971 Convention on Psychotropic Substances in 2001 based on the drug’s abrupt introduction to the market (United Nations Office on Drugs and Crime [UNODC], 1971; de Boer and Boeman, 2004).

It was designated as an NPS by the European Monitoring Center for Drug and Drug Addiction (EMCDDA) and the United Nations Office on Drugs and Crime (UNDOC) (European Monitoring Center for Drug and Drug Addiction [EMCDDA], 2011; United Nations Office on Drugs and Crime [UNODC], 2013).

Due to its recent arrival on the market, 2C-B is also regarded as an NPS in some countries in Latin America, including Colombia (Clombian National Study on Psychoactive Substance Consumption, 2013).

Data on the prevalence and usage patterns of novel psychotherapeutics are restricted. 2,282 respondents (46.4%) to the Global Drug Survey (GDS) (2013) reported using at least one NPS in their lives. Of them, 21.7 percent described lifetime use of psychedelic phenethylamine, with 18.4 percent falling under the 2C family, with 2C-B accounting for the highest percentage (n = 291, 12.97%) (Palamar et al., 2016).

In Australia, a survey of regular users of ecstasy revealed that 44% had used an NPS in the previous six months, with just 2C-I (14%) and 2C-B (8%), respectively (Burn et al., 2014).

In a cross-sectional survey conducted among 230 research chemical users, 2C-B was the most frequently used drug (80.0 percent ). The most frequent combinations were 2C-B and MDMA (28.3 percent), followed by 7.4, 5.7, 3.9, and 2.6 percent, respectively, of 2C-B with amphetamine, LSD, ketamine, and Methylone (González et al., 2013).

The most recent GDS data, which comprised a non-representative sample of 115,000 participants, indicate a surge in the use of drugs with psychedelic effects, including LSD analogs, accounting for more than half of all NPSs.